1-Methylimidazole → HCID 86655181, compound

HRID 874167Notes

Reaction equation

HRID 874167 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[CH:3]1.[CH3:7][O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][Br:14])=[CH:11][CH:10]=1>C1(C)C=CC=CC=1>[Br-:14].[CH3:7][O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][N:4]2[CH:5]=[CH:6][N+:2]([CH3:1])=[CH:3]2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 13901-MethylimidazoleHCID 1650214-Methoxybenzyl bromide

Product 1

HCID 86655181HCID 86655181, compoundYield 131.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Into a 50 ml one-necked flask surmounted by a condenser, there are successively introduced 1 ml (12.5 mmol) of N-methylimidazole, and then 5 g (18.8 mmol) of 4-methoxybenzyl bromide in solution in 25 ml of toluene. The reaction medium is heated under reflux, with stirring, for 2 h 30 min. After cooling to room temperature, the viscous oil formed is separated by decantation and then dried under vacuum at room temperature, 4.65 g of a pale yellow solid are thus obtained whose characteristics are the following:

Workup

  1. customInto a 50 ml one-necked flask surmounted by a condenser
  2. temperatureThe reaction medium is heated
  3. temperatureunder reflux
  4. customthe viscous oil formed
  5. customis separated by decantation
  6. customdried under vacuum at room temperature

Sources & evidence

ORD record
ord-7a6363acd9e84fdfaef1dcb5fb9a898e
Source dataset
uspto-grants-2015_03
Patent number
US08980875B2

Reaction notes

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