Potassium Carbonate → HCID 67125226, compound

Participants

Reaction Conditions

Reaction Steps

5.00 g (14.4 mmol) of methyl 2-(bromomethyl)-4-(2-chlorophenyl)-1,3-thiazole-5-carboxylate were added to a solution of 10.00 g (18.7 mmol) of trifluoromethyltetrazole sodium salt in 100 ml of acetonitrile. Then 600 mg (4.32 mmol) of potassium carbonate were added to the reaction solution, and the mixture was stirred at 60° C. for 6 hours. After cooling to room temperature, the reaction solution was filtered and the mother liquor was freed from the solvent under reduced pressure. 10 ml of water were added to the residue and the mixture was extracted with ethyl acetate (3×20 ml). The combined organic phases were dried over sodium sulphate. The solvent was removed under reduced pressure and the residue was purified by chromatography. (logP: 3.60; MH+: 404; 1H-NMR (400 MHz, DMSO, ppm): 3.71 (s, 3H), 6.70 (s, 2H), 7.40-7.60 (m, 4H).

Provenance & Evidence