Sodium Hydroxide → HCID 53251661, compound

HRID 874196Notes

Reaction equation

HRID 874196 reaction equation
[Cl-].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:31]=[CH:32][CH:33]=1)[C:7]([NH:9][C:10]1[CH:24]=[CH:23][C:13]([O:14][CH2:15][CH2:16][NH+:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[C:12]([C:25]2[N:29]([CH3:30])[N:28]=[CH:27][CH:26]=2)[CH:11]=1)=[O:8].[OH-].[Na+]>O>[OH2:3].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:31]=[CH:32][CH:33]=1)[C:7]([NH:9][C:10]1[CH:24]=[CH:23][C:13]([O:14][CH2:15][CH2:16][N:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)=[C:12]([C:25]2[N:29]([CH3:30])[N:28]=[CH:27][CH:26]=2)[CH:11]=1)=[O:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 672566504-(2-(4-(3-Methoxybenzamido)-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)ethyl)morpholin-4-ium chloride

Product 1

HCID 53251661HCID 53251661, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

100 mg of 4-(2-(4-(3-methoxybenzamido)-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)ethyl)morpholin-4-ium chloride were added to 3 mL of H2O in a 4 mL vial. The solution was stirred until it became clear. 225 μL of 1 N NaOH was added to the vial to reach a pH of ˜8. A white precipitate formed. The solution was stirred for 1 hour at room temperature. The crystalline materials formed on the side of the vial were scraped off, and the solution was filtered using centrifuge tube filters. The material was dried overnight in the hood.

Workup

  1. customA white precipitate formed
  2. stirringThe solution was stirred for 1 hour at room temperature
  3. customThe crystalline materials formed on the side of the
  4. filtrationthe solution was filtered
  5. customThe material was dried overnight in the hood

Sources & evidence

ORD record
ord-499d750a5f6b4379b612091a5ba7acf2
Source dataset
uspto-grants-2015_03
Patent number
US08980891B2

Reaction notes

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