(2-Methoxyethyl)((pyridin-2-yl)methyl)amine → N-(2-methoxyethyl)-N-(2-pyridinylmethyl)-2-(4-chlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetamide.hydrochloride

Participants

Reaction Steps

According to the method of Example 14, 2-(4-chlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetic acid and N-(2-pyridinylmethyl)-2-methoxyethylamine were used as raw materials for synthesis, white solid powder, yield 46.0%. m.p. 238-239° C., ESI-MS m/z: 450[M+H]+, 1H NMR(D2O, 400 MHz)δ: 2.37(s, 2.5H), 2.39(s, 0.5H), 3.10(s, 0.5H), 3.14(s, 2.5H), 3.52(t, 2H, J=4.76 Hz) 3.74(t, 2H, J=4.76 Hz), 4.15(s, 0.4H), 4.41(s, 1.6H), 4.76(s, 1.6H), 4.85(s, 0.4H), 7.15-7.23(m, 1H), 7.30-7.47(m, 4H), 7.50(s, 1H), 7.60-7.70(m, 2H), 8.09-8.11(m, 1H), 8.25-8.45(m, 2H).

Provenance & Evidence