N-(pyridin-2-ylmethyl)ethanamine → N-ethyl-N-(2-pyridinylmethyl)-2-(3,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetamide.hydrochloride

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Reaction Steps

According to the method of Example 14, 2-(3,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetic acid and N-(2-pyridinylmethyl)ethylamine were used as raw materials for synthesis, white solid powder, yield 75.5%. m.p. 217-220° C., ESI-MS m/z: 454[M+H]+, 1H NMR(DMSO-d6, 400 MHz)δ: 0.99(t, 1.5H, J=7.00 Hz), 1.25(t, 1.5H, J=7.00 Hz), 2.57(s, 1.5H), 2.60(s, 1.5H), 3.33(q, 1H, J=7.00 Hz), 3.65(q, 1H, J=7.00 Hz), 4.56(s, 1H), 4.59(s, 1H), 4.78(s, 1H), 4.86(s, 1H), 7.40-7.53(m, 1H), 7.54-7.68(m, 2H), 7.78-7.81(m, 1H), 7.89(s, 1H), 7.91-7.95(m, 1H), 8.62-8.67(m, 2H), 8.84-8.86(m, 2H).

Provenance & Evidence