Ethyl[(pyridin-3-yl)methyl]amine → N-ethyl-N-(3-pyridinylmethyl)-2-(3,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetamide.hydrochloride

Participants

Reaction Steps

According to the method of Example 14, 2-(3,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetic acid and N-(3-pyridinylmethyl)ethylamine were used as raw materials for synthesis, to obtain white solid powder, yield 70.8%. m.p. 245-248° C., ESI-MS m/z: 454[M+H]+, 1H NMR(DMSO-d6, 400 MHz)δ: 1.06(t, 0.7H, J=7.00 Hz), 1.25(t, 2.3H, J=7.00 Hz), 2.58(s, 3H), 3.34(q, 0.5H, J=7.00 Hz), 3.58(q, 1.5H, J=7.00 Hz), 4.45(s, 0.5H), 4.57(s, 1.5H), 4.70(s, 1.5H), 4.92(s, 0.5H), 7.44-7.47(d, 1H, J=7.00 Hz), 7.56(dd, 0.2H, J=8.40 Hz, 1.96 Hz), 7.63(dd, 0.8H, J=8.40 Hz, 2.24 Hz), 7.80(s, 1H), 7.86(d, 0.2H, J=2.24 Hz), 7.87(d, 0.8H, J=1.96 Hz), 7.90(m, 1H), 7.94(d, 1H, J=8.40 Hz), 8.30-8.31(m, 1H), 8.74-8.77(m, 1H), 8.79(d, 1H, J=7.00 Hz), 8.82(m, 1H).

Provenance & Evidence