(2-Methoxyethyl)((pyridin-2-yl)methyl)amine → N-(2-methoxyethyl)-N-(2-pyridinylmethyl)-2-(3,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetamide.hydrochloride

Participants

Reaction Steps

According to the method of Example 14, 2-(3,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetic acid and N-(2-pyridinylmethyl)-2-methoxyethylamine were used as raw materials for synthesis, to obtain light yellow solid powder, yield 68.6%. m.p. 236-238° C., ESI-MS m/z: 484[M+H]+, 1H NMR(DMSO-d6, 400 MHz)δ: 2.57(s, 2H), 2.60(s, 1H), 3.16(s, 1H), 3.27(s, 2H), 3.40(t, 0.7H, J=4.76 Hz), 3.47(t, 0.7H, J=4.76 Hz), 3.60(t, 1.3H, J=4.76 Hz), 3.84(t, 1.3H, J=4.76 Hz), 4.56(s, 0.7H), 4.66(s, 1.3H), 4.84(s, 1.3H), 4.93(s, 0.7H), 7.43-7.50(m, 1H), 7.62-7.65(dd, 1H, J=8.40 Hz, 2.24 Hz), 7.69-7.81(m, 2H), 7.88-7.90(d, 1H, J=8.40 Hz), 7.92-7.93(d, 1H, J=2.24 Hz), 7.95(s, 1H), 8.62-8.78(m, 2H), 8.76-8.84(m, 1H).

Provenance & Evidence