(2-Methoxyethyl)(pyridin-3-ylmethyl)amine → N-(2-methoxyethyl)-N-(3-pyridinylmethyl)-2-(3,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetamide.hydrochloride

Participants

Reaction Steps

According to the method of Example 14, 2-(3,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetic acid and N-(3-pyridinylmethyl)-2-methoxyethylamine were used as raw materials for synthesis, to obtain white solid powder, yield 74.4%. m.p. 235-237° C., ESI-MS m/z: 484[M+H]+, 1H NMR(DMSO-d6, 400 MHz)δ: 2.58(s, 3H), 3.20(s, 0.3H), 3.26(s, 2.7H), 3.57(t, 2H, J=4.76 Hz), 3.76(t, 2H, J=4.76 Hz), 4.43(s, 0.2H), 4.62(s, 1.8H), 4.74(s, 1.8H), 4.97(s, 0.2H), 7.47-7.48(d, 1H, J=7.00 Hz), 7.61(dd, 1H, J=8.4 Hz, 2.24 Hz), 7.8(s, 1H), 7.87-7.88(m, 1H), 7.91-7.92(d, 1H, J=2.24 Hz), 7.95-7.97(d, 1H, J=8.40 Hz), 8.27-8.29(m, 1H), 8.66-8.68(d, 1H, J=7.00 Hz), 8.75-8.79(m, 2H).

Provenance & Evidence