Hydrochloric Acid → HCID 67071560, compound

Participants

Reaction Conditions

Reaction Steps

HCl 20% aq. (5 ml, 30 mmol) was added to a suspension of (±)-(E)-3-[1-tert-butoxycarbonyl-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid methyl ester (Intermediate 1, Step B) (464 mg, 1.2 mmol) in glacial AcOH (5 ml). The mixture was stirred at 85° C. for 3 h and then evaporated under vacuum to give (±)-(E)-3-[4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid (370 mg) as a white solid (hydrochloride salt).

Provenance & Evidence