O-(Tetrahydropyran-2-yl)hydroxylamine → HCID 86671979, compound

HRID 874233Notes

Reaction equation

HRID 874233 reaction equation
Cl.[CH2:2]([N:9]1[CH2:13][CH2:12][C:11]2([CH2:22][C:21](=[O:23])[C:20]3[C:15](=[CH:16][CH:17]=[C:18](/[CH:24]=[CH:25]/[C:26](O)=[O:27])[CH:19]=3)[O:14]2)[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[NH2:29][O:30][CH:31]1[CH2:36][CH2:35][CH2:34][CH2:33][O:32]1>>[CH2:2]([N:9]1[CH2:13][CH2:12][C:11]2([CH2:22][C:21](=[O:23])[C:20]3[C:15](=[CH:16][CH:17]=[C:18](/[CH:24]=[CH:25]/[C:26]([NH:29][O:30][CH:31]4[CH2:36][CH2:35][CH2:34][CH2:33][O:32]4)=[O:27])[CH:19]=3)[O:14]2)[CH2:10]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 5142091O-(Tetrahydropyran-2-yl)hydroxylamineHCID 67071476HCID 67071476, compound

Product 1

HCID 86671979HCID 86671979, compound

Procedure

(±)-(E)-3-[1′Benzyl-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid hydrochloride salt (450 mg, 1.12 mmol) was treated with NH2OTHP following the procedure described in Example 1, Step C, giving (±)-(E)-3-[1′-benzyl-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (226 mg) as a light yellow solid.

Sources & evidence

ORD record
ord-36acd13732e94722a86ee9b53f388ea2
Source dataset
uspto-grants-2015_03
Patent number
US08980877B2

Reaction notes

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