Hydrochloric Acid → HCID 51051073, compound

Participants

Reaction Steps

1 M HCl in Et2O (5 ml, 5 mmol) was added dropwise to a solution of (±)-(E)-3-[1′-benzyl-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (172 mg, 0.37 mmol) in DCM (3 ml). After 1 h stirring a white solid precipitated, which was then filtered off, washed with DCM, dried under vacuum and collected to give 83 mg of (±)-(E)-3-[1′-benzyl-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-N-hydroxy-acrylamide as its hydrochloride salt.

Provenance & Evidence