4-Fluorobenzaldehyde → HCID 67071636, compound

Participants

Reaction Steps

A suspension of Intermediate 1 (250 mg, 0.77 mmol) in aqueous 10% NaHCO3 solution was extracted with DCM (3×10 ml). The organic phase was dried over Na2SO4 and evaporated. The resulting solid was dissolved in DCM (10 ml), treated with 4-fluoro-benzaldehyde (0.090 ml, 0.85 mmol) and NaBH(OAc)3 (245 mg, 1.15 mmol) as described in Example 2, Step A, to give (±)-(E)-3-[1′-(4-fluoro-benzyl)-4-oxo-spiro(chromane-2,3′-pyrrolidine)-6-yl]-acrylic acid methyl ester (300 mg, 0.76 mmol, 99%) as a light brown solid.

Provenance & Evidence