Hydrochloric Acid → HCID 51356716, compound

Participants

Reaction Steps

1 M HCl in Et2O (5 ml, 5 mmol) was added dropwise to a solution of (E)-3-[1′-benzyl-4-oxo-spiro(chromane-2,3′-piperidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (260 mg, 0.55 mmol) in DCM (3 ml). After 1 h a white solid precipitated, which was filtered, washed with DCM, dried under vacuum and purified by preparative HPLC to give 180 mg of (±)-(E)-3-[1′-benzyl-4-oxo-spiro(chromane-2,3′-piperidine)-6-yl]-N-hydroxy-acrylamide as its trifluoroacetic salt.

Provenance & Evidence