Sodium Hydroxide → HCID 67071459, compound

HRID 874262Notes

Reaction equation

C[O:2][C:3](=[O:30])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:26](=[CH:27][CH:28]=1)[O:25][C:11]1([CH2:16][CH2:15][CH2:14][N:13]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[CH2:12]1)[CH2:10][C:9]2=[O:29].[OH-].[Na+]>>[F:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:13]2[CH2:14][CH2:15][CH2:16][C:11]3([CH2:10][C:9](=[O:29])[C:8]4[C:26](=[CH:27][CH:28]=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:30])=[O:2])[CH:7]=4)[O:25]3)[CH2:12]2)=[CH:19][CH:20]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 67071603HCID 67071603, compound

Product 1

HCID 67071459HCID 67071459, compoundYield 85%

Procedure

(±)-(E)-3-[1′-(4-Fluoro-benzyl)-4-oxo-spiro(chromane-2,3′-piperidine)-6-yl]-acrylic acid methyl ester (630 mg, 1.54 mmol) was treated with 1 M NaOH according to the procedure described in Example 16 STEP B to give (±)-(E)-3-[1′-(4-fluoro-benzyl)-4-oxo-spiro(chromane-2,3′-piperidine)-6-yl]-acrylic acid (516 mg, 85%).

Sources & evidence

ORD record: ord-050969bf9c4e4ca7bbb28e3b26977bb2
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08980877B2

Reaction notes

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