Hydrochloric Acid → HCID 67071671, compound

Participants

Reaction Conditions

Reaction Steps

20% aqueous HCl (10 ml, 55 mmol) was added to a suspension of (±)-(E)-3-[1′-tert-butoxycarbonyl-4-oxo-spiro(chromane-2,4′-azepane)-6-yl]-acrylic acid methyl ester (Intermediate 3, Step B, 954 mg, 2.3 mmol) in glacial AcOH (10 ml). The mixture was stirred at 85° C. for 3 h and then evaporated under vacuum to give (±)-(E)-3-[4-oxo-spiro(chromane-2,4′-azepane)-6-yl]-acrylic acid (735 mg) as a white solid (hydrochloride salt).

Provenance & Evidence