Hydrochloric Acid → HCID 51357551, compound

Participants

Reaction Steps

4 M HCl in dioxane (1.90 ml) was added dropwise to a solution of (E)-3-[1′-tert-butoxycarbonyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (360 mg, 0.78 mmol) in DCM (14 ml). The mixture was stirred at RT overnight. The formed precipitate was filtered off, washed with DCM, dried under vacuum to give (E)-3-[4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-N-hydroxy-acrylamide (154 mg, hydrochloride salt) as a white solid.

Provenance & Evidence