Formaldehyde → HCID 67071595, compound

Participants

Reaction Steps

(E)-3-[1′-Methyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid methyl ester was synthesized starting from Intermediate 4 (500 mg, 1.62 mmol), according to the procedure for preparation of Example 31, Step A, using aqueous 37% formaldehyde solution (0.088 ml, 3.2 mmol), and NaBH(OAc)3 (515 mg, 2.43 mmol). The product was obtained as pale yellow oil (430 mg).

Provenance & Evidence