Potassium Carbonate → HCID 67071507, compound

Participants

Reaction Conditions

Reaction Steps

K2CO3 (285 mg, 2.06 mmol) and 1-(2-bromoethyl)-4-fluorobenzene (0.43 ml, 3.1 mmol) were added to a suspension of Intermediate 4 (320 mg, 1.04 mmol) in acetonitrile (30 ml) and the mixture was stirred at 70° C. for 54 h. The solvent was evaporated and the residue was partitioned between water and DCM. The organic phase was dried over Na2SO4, filtered and evaporated. The crude residue was purified by column chromatography on silica gel (eluent:petroleum ether:EtOAc 6:4) to give (E)-3-{1′-[2-(4-fluoro-phenyl)-ethyl]-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl}-acrylic acid methyl ester (120 mg) as a brown oil.

Provenance & Evidence