Sodium Hydroxide → HCID 67071645, compound

HRID 874296Notes

Reaction equation

C[O:2][C:3](=[O:23])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:19](=[CH:20][CH:21]=1)[O:18][C:11]1([CH2:14][N:13]([C:15](=[O:17])[CH3:16])[CH2:12]1)[CH2:10][C:9]2=[O:22].[OH-].[Na+]>>[C:15]([N:13]1[CH2:12][C:11]2([CH2:10][C:9](=[O:22])[C:8]3[C:19](=[CH:20][CH:21]=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:23])=[O:2])[CH:7]=3)[O:18]2)[CH2:14]1)(=[O:17])[CH3:16]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 67071509HCID 67071509, compound

Product 1

HCID 67071645HCID 67071645, compoundYield 46.9%

Procedure

(E)-3-[1′-Acetyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid methyl ester (270 mg, 0.85 mmol) was hydrolyzed with 1 M NaOH (1.1 ml) following the procedure described in Example 30, Step A, giving (E)-3-[1′-acetyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid (120 mg, hydrochloride salt) as a brown solid.

Sources & evidence

ORD record: ord-09396da4d91c48dd9d47e2b317ce946d
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08980877B2

Reaction notes

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