Sodium Hydroxide → HCID 67071523, compound

HRID 874300Notes

Reaction equation

C[O:2][C:3](=[O:28])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:24](=[CH:25][CH:26]=1)[O:23][C:11]1([CH2:14][N:13]([C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:12]1)[CH2:10][C:9]2=[O:27].[OH-].[Na+]>>[C:15]([N:13]1[CH2:14][C:11]2([CH2:10][C:9](=[O:27])[C:8]3[C:24](=[CH:25][CH:26]=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:28])=[O:2])[CH:7]=3)[O:23]2)[CH2:12]1)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 67071535HCID 67071535, compound

Product 1

HCID 67071523HCID 67071523, compoundYield 60.5%

Procedure

(E)-3-[1′-Benzoyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid methyl ester (380 mg, 1.0 mmol) was hydrolyzed with 1 M NaOH following the procedure described in Example 30, Step A, giving (E)-3-[1′-benzoyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid (220 mg, hydrochloride salt) as a light brown solid.

Sources & evidence

ORD record: ord-e8120cc2787e4b5ab7a36d1b6f0f8123
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08980877B2

Reaction notes

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