Sodium Hydroxide → HCID 67071515, compound

HRID 874304Notes

Reaction equation

C[O:2][C:3](=[O:25])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[C:8]2[C:21](=[CH:22][CH:23]=1)[O:20][C:11]1([CH2:14][N:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:12]1)[CH2:10][C:9]2=[O:24].[OH-].[Na+]>>[CH2:18]([O:17][C:15]([N:13]1[CH2:14][C:11]2([CH2:10][C:9](=[O:24])[C:8]3[C:21](=[CH:22][CH:23]=[C:6](/[CH:5]=[CH:4]/[C:3]([OH:25])=[O:2])[CH:7]=3)[O:20]2)[CH2:12]1)=[O:16])[CH3:19]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 67071569HCID 67071569, compound

Product 1

HCID 67071515HCID 67071515, compoundYield 70.2%

Procedure

(E)-3-[1′-Ethyloxycarbonyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid methyl ester (300 mg, 0.86 mmol) was hydrolyzed with 1 M NaOH following the procedure described in Example 30, Step A, giving (E)-3-[1′-ethyloxycarbonyl-4-oxo-spiro(chromane-2,3′-azetidine)-6-yl]-acrylic acid (200 mg, hydrochloride salt) as a yellow solid.

Sources & evidence

ORD record: ord-c1c7d6db10704cb1a4842466d020b5f7
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08980877B2

Reaction notes

Loading…