Pyridine → HCID 86671999, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (E)-3-(1′-(4-fluorobenzyl)-4-oxospiro[chroman-2,3′-piperidine]-6-yl)-N-hydroxyacrylamide hydrochloride (80 mg, 0.179 mmol) and O-methylhydroxylamine hydrochloride (32.6 mg, 0.390 mmol) in ethanol (2 ml) and pyridine (0.031 ml, 0.390 mmol) was heated at 80° C. for 2 h. The solvent was removed in vacuo and the crude product was purified by preparative LC-MS to give the title compound (33.04 mg) as its trifluoroacetate salt.

Provenance & Evidence