Sodium Hydroxide → HCID 117761285, compound

HRID 874342Notes

Reaction equation

HRID 874342 reaction equation
[OH-].[Na+:2].[CH3:3][C:4]1[N:5]=[C:6]([C:10]2[CH:11]=[N:12][N:13]([CH3:19])[C:14]=2[C:15]([O:17]C)=[O:16])[S:7][C:8]=1[CH3:9]>CO>[CH3:3][C:4]1[N:5]=[C:6]([C:10]2[CH:11]=[N:12][N:13]([CH3:19])[C:14]=2[C:15]([O-:17])=[O:16])[S:7][C:8]=1[CH3:9].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 90383255HCID 90383255, compound

Product 1

HCID 117761285HCID 117761285, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An aqueous solution (1 ml) of sodium hydroxide (9.6 mg) was added to a methanol (1 ml) solution of the methyl 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate (30 mg) obtained in (Example 2.2) <Step 1>, and the obtained mixture was then heated to reflux for 15 minutes. Thereafter, the solvent was distilled away under reduced pressure, and the residue was then subjected to azeotropy with toluene, so as to obtain a crude product of the title compound.

Workup

  1. customobtained in (Example 2.2) <Step 1>
  2. temperaturethe obtained mixture was then heated
  3. temperatureto reflux for 15 minutes
  4. distillationThereafter, the solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-be8ab7e1939a4165bb01fa52b1e8788b
Source dataset
uspto-grants-2015_03
Patent number
US08980888B2

Reaction notes

Loading…