Ethanol → 7-chloro-N-[(3-methoxypiperidin-4-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide

HRID 87438Notes

Reaction equation

HRID 87438 reaction equation
[CH3:31][CH2:32][OH:33].[Cl:1][c:2]1[cH:3][c:4]([C:12](=[O:13])[NH:14][CH2:15][CH:16]2[CH:17]([O:27][CH3:28])[CH2:18][N:19]([C:22]([O:23][CH2:24][CH3:25])=[O:26])[CH2:20][CH2:21]2)[c:5]2[c:6]([cH:11]1)[O:7][CH2:8][CH2:9][O:10]2.[K+:30].[OH-:29]>>[Cl:1][c:2]1[cH:3][c:4]([C:12](=[O:13])[NH:14][CH2:15][CH:16]2[CH:17]([O:27][CH3:28])[CH2:18][NH:19][CH2:20][CH2:21]2)[c:5]2[c:6]([cH:11]1)[O:7][CH2:8][CH2:9][O:10]2

Participants

5

Reactant 4

HCID 702EthanolHCID 813Potassium CationHCID 961HydroxideHCID 18613663Ethyl 4-[[[(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)carbonyl]-amino]methyl]-3-methoxy-1-piperidinecarboxylate

Product 1

HCID 186136607-chloro-N-[(3-methoxypiperidin-4-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide

Sources & evidence

ORD record
ord-3974e38293d1452bb7fb30767e0f0899
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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