1,4-Dioxane hydrochloride → HCID 117776661, compound

HRID 874408Notes

Reaction equation

HRID 874408 reaction equation
[ClH:1].O1CCOCC1.[F:8][C:9]1[CH:10]=[C:11]([C:15]2[N:16]=[C:17]3[CH2:22][CH:21]([NH:23]C(=O)OC(C)(C)C)[CH2:20][CH2:19][N:18]3[CH:31]=2)[CH:12]=[CH:13][CH:14]=1>>[ClH:1].[F:8][C:9]1[CH:10]=[C:11]([C:15]2[N:16]=[C:17]3[CH2:22][CH:21]([NH2:23])[CH2:20][CH2:19][N:18]3[CH:31]=2)[CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 90383257Tert-butyl (2-(3-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-yl)carbamate

Product 1

HCID 117776661HCID 117776661, compound

Procedure

A 4 N hydrochloric acid-1,4-dioxane solution (5 ml) was added to the tert-butyl (2-(3-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-7-yl)carbamate (116 mg) obtained in (Example 2.7) <Step 5>, and the obtained mixture was then stirred for 1 hour. Thereafter, the solvent was distilled away under reduced pressure, and the title compound (133 mg) was obtained in the form of a colorless solid.

Workup

  1. customobtained in (Example 2.7) <Step 5>
  2. distillationThereafter, the solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-d790c4416fc746bb823e23042d2db4f2
Source dataset
uspto-grants-2015_03
Patent number
US08980889B2

Reaction notes

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