4-Nitrobenzyl bromide → 1-(Methanesulfonylmethyl)-4-nitrobenzene

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-nitrobenzyl bromide (10.0 g, 46.4 mmol) in dimethylformamide (25 mL) was added sodium methanesulfinate (7.10 g, 69.6 mmol). The reaction mixture was stirred at 65° C. for 1 hour. The reaction mixture was cooled to ambient temperature, diluted with water, stirred for 10 minutes and filtered to give the title compound (9.27 g, 93%).

Provenance & Evidence