反应详情

温度

65 °C

A 250 mL round-bottomed flask was charged with 4-bromobenzyl bromide (5 g, 20 mmol) and N,N-dimethylformamide (10.81 mL). Sodium methanesulfinate (3.06 g, 30 mmol) was added. The reaction mixture was stirred at 65° C. for 1 hour. The reaction mixture was cooled to ambient temperature and diluted with water. The resulting suspension was stirred for 10 minutes and filtered. The solid was rinsed with water and dried under house vacuum over the weekend to provide 4.75 g (95%) of the title compound.

1. temperatureThe reaction mixture was cooled to ambient temperature
2. stirringThe resulting suspension was stirred for 10 minutes
3. filtrationfiltered
4. washThe solid was rinsed with water
5. customdried under house vacuum over the weekend