2-Aminopyridine → HCID 90387822, compound

Participants

Reaction Steps

A mixture of Example 23a (0.122 g, 0.405 mmol) and 2-aminopyridine (0.042 g, 0.445 mmol) in dimethyl sulfoxide (6 mL) was treated with potassium 2-methylpropan-2-olate (0.091 g, 0.81 mmol) and stirred at ambient temperature for 23.5 hours. The reaction mixture was partitioned between ethyl acetate and water, washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified by flash chromatography (silica gel, 0-15% ethyl acetate in dichloromethane) to give 0.117 g (77%) of the title compound.

Provenance & Evidence