HCID 66871114, compound → HCID 66870629, compound

HRID 874567Notes

Reaction equation

CS(C1CCN([C@@H](C[NH:17][S:18]([C:21]2C=CC(OCC3C4C(=CC=CC=4)N=C(C)C=3)=CC=2)(=[O:20])=[O:19])C(OC)=O)CC1)(=O)=O.CS(C1[CH2:49][CH2:48][N:47]([C@@H:50]([CH2:54][NH:55][S:56]([C:59]2[CH:64]=[CH:63][C:62]([O:65][CH2:66][C:67]3[C:76]4[C:71](=[CH:72][CH:73]=[CH:74][CH:75]=4)[N:70]=[C:69]([CH3:77])[CH:68]=3)=[CH:61][CH:60]=2)(=[O:58])=[O:57])[C:51]([OH:53])=[O:52])[CH2:46][CH2:45]1)(=O)=O>>[CH3:21][S:18]([N:17]1[CH2:45][CH2:46][N:47]([C@@H:50]([CH2:54][NH:55][S:56]([C:59]2[CH:64]=[CH:63][C:62]([O:65][CH2:66][C:67]3[C:76]4[C:71](=[CH:72][CH:73]=[CH:74][CH:75]=4)[N:70]=[C:69]([CH3:77])[CH:68]=3)=[CH:61][CH:60]=2)(=[O:58])=[O:57])[C:51]([OH:53])=[O:52])[CH2:48][CH2:49]1)(=[O:20])=[O:19]

Participants

Reactant 2

HCID 66871114HCID 66871114, compound

HCID 86675017HCID 86675017, compound

Product 1

HCID 66870629HCID 66870629, compound

Procedure

In a manner analogous to example 3.7, using 130 mg (0.2 mmol) of methyl (S)-2-(4-methanesulfonyl-piperidin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate, 120 mg (99%) of (S)-2-(4-methanesulfonylpiperidin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]-propanoic acid are obtained in the form of a white solid.

Workup

customare obtained in the form of a white solid

Sources & evidence

ORD record: ord-2351a333f88e4a34981ef17f9ab97eb0
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08980897B2

Reaction notes

Loading…