HCID 49847471, compound → HCID 75303849, compound

HRID 874579Notes

Reaction equation

HRID 874579 reaction equation
FC1C=CC(CN2CCN(C(CNS(C3C=CC(OCC4C5C(=CC=CC=5)N=C(C)C=4)=CC=3)(=O)=O)C(O)=O)CC2)=CC=1.[F:43][C:44]1[CH:85]=[CH:84][C:47]([CH2:48][N:49]2[CH2:54][CH2:53][N:52]([C@@H:55]([CH2:60][NH:61][S:62]([C:65]3[CH:70]=[CH:69][C:68]([O:71][CH2:72][C:73]4[C:82]5[C:77](=[CH:78][CH:79]=[CH:80][CH:81]=5)[N:76]=[C:75]([CH3:83])[CH:74]=4)=[CH:67][CH:66]=3)(=[O:64])=[O:63])[C:56]([NH:58][OH:59])=[O:57])[CH2:51][CH2:50]2)=[CH:46][CH:45]=1>>[F:43][C:44]1[CH:45]=[CH:46][C:47]([CH2:48][N:49]2[CH2:54][CH2:53][N:52]([CH:55]([CH2:60][NH:61][S:62]([C:65]3[CH:66]=[CH:67][C:68]([O:71][CH2:72][C:73]4[C:82]5[C:77](=[CH:78][CH:79]=[CH:80][CH:81]=5)[N:76]=[C:75]([CH3:83])[CH:74]=4)=[CH:69][CH:70]=3)(=[O:63])=[O:64])[C:56]([NH:58][OH:59])=[O:57])[CH2:51][CH2:50]2)=[CH:84][CH:85]=1

Participants

3

Reactant 2

HCID 49847471HCID 49847471, compoundHCID 66871031HCID 66871031, compound

Product 1

HCID 75303849HCID 75303849, compound

Procedure

In a manner analogous to example 3.8, using 990 mg (1.7 mmol) of (S)-2-[4-(4-fluorobenzyl)-piperazin-1-yl-3-(4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoic acid, 330 mg (33%) of (S)-2-[4-(4-fluorobenzyl)piperazin-1-yl]-N-hydroxy-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propionamide are obtained in the form of a white solid with a melting point of 180° C.

Workup

  1. customare obtained in the form of a white solid with a melting point of 180° C.

Sources & evidence

ORD record
ord-129403371fc3458988e92fded283f30d
Source dataset
uspto-grants-2015_03
Patent number
US08980897B2

Reaction notes

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