HCID 86675029, compound → HCID 86715682, compound

HRID 874592Notes

Reaction equation

HRID 874592 reaction equation
C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][N:18]([S:21]([CH2:24][CH:25]([CH3:27])[CH3:26])(=[O:23])=[O:22])[CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:28].Cl.NC[C@H](N1CCN(S(CC(C)C)(=O)=O)CC1)C(OC)=O>>[ClH:28].[ClH:28].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][N:18]([S:21]([CH:24]=[C:25]([CH3:27])[CH3:26])(=[O:23])=[O:22])[CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12]

Participants

3

Reactant 2

HCID 86675029HCID 86675029, compoundHCID 86715684methyl (S)-3-amino-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]propanoate dihydrochloride

Product 1

HCID 86715682HCID 86715682, compound

Procedure

In a manner analogous to example 3.3, using 785 mg (1.9 mmol) of methyl (S)-3-tert-butoxycarbonylamino-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]propanoate, 621 mg (85%) of methyl (S)-3-amino-2-[4-(2-methylpropane-1-sulfonyl)piperazin-1-yl]propanoate dihydrochloride are obtained in the form of a solid.

Workup

  1. customare obtained in the form of a solid

Sources & evidence

ORD record
ord-c47a7cd4f28d4beab52a4a4a6cb5ec15
Source dataset
uspto-grants-2015_03
Patent number
US08980897B2

Reaction notes

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