4-(2-Methylquinolin-4-ylmethoxy)benzenesulfonyl chloride hydrochloride → HCID 86715688, compound

HRID 874596Notes

Reaction equation

HRID 874596 reaction equation
Cl.Cl.NC[C@H](N1CCN(S(C(C)C)(=O)=O)CC1)C(OC)=O.Cl.CC1C=C(COC2C=CC(S(Cl)(=O)=O)=CC=2)C2C(=CC=CC=2)N=1.[CH3:46][C:47]1[CH:56]=[C:55]([CH2:57][O:58][C:59]2[CH:64]=[CH:63][C:62]([S:65]([NH:68][CH2:69][C@H:70]([N:75]3[CH2:80][CH2:79][N:78]([S:81]([CH:84]([CH3:86])[CH3:85])(=[O:83])=[O:82])[CH2:77][CH2:76]3)[C:71]([O:73][CH3:74])=[O:72])(=[O:67])=[O:66])=[CH:61][CH:60]=2)[C:54]2[C:49](=[CH:50][CH:51]=[CH:52][CH:53]=2)[N:48]=1>>[CH3:46][C:47]1[CH:56]=[C:55]([CH2:57][O:58][C:59]2[CH:64]=[CH:63][C:62]([S:65]([NH:68][CH2:69][C@H:70]([N:75]3[CH2:80][CH2:79][N:78]([S:81]([C:84]([CH3:86])=[CH2:85])(=[O:82])=[O:83])[CH2:77][CH2:76]3)[C:71]([O:73][CH3:74])=[O:72])(=[O:67])=[O:66])=[CH:61][CH:60]=2)[C:54]2[C:49](=[CH:50][CH:51]=[CH:52][CH:53]=2)[N:48]=1

Participants

4

Reactant 3

HCID 866078654-(2-Methylquinolin-4-ylmethoxy)benzenesulfonyl chloride hydrochlorideHCID 86715689HCID 86715689, compoundHCID 86715691HCID 86715691, compound

Product 1

HCID 86715688HCID 86715688, compound

Procedure

In a manner analogous to example 17.6, using 620 mg (1.5 mmol) of methyl (S)-3-amino-2-[4-(propane-2-sulfonyl)piperazin-1-yl]propanoate dihydrochloride and 830 mg (2.1 mmol) of 4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl chloride hydrochloride (prepared as described in the example 17.2), 505 mg (54%) of methyl (S)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]-2-[4-(propane-2-sulfonyl)piperazin-1-yl]propanoate are obtained in the form of a white solid.

Workup

  1. customprepared
  2. customare obtained in the form of a white solid

Sources & evidence

ORD record
ord-62a3c95c98fe48edbbae9076416c4d64
Source dataset
uspto-grants-2015_03
Patent number
US08980897B2

Reaction notes

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