反应详情

10% Pd/C (38 mg, 35 μmol, 10 mol % Pd) was added to chloride 3 (113 mg, 353 μmol) in ethanol:dichloromethane (3:1, 4.0 mL). The mixture was degassed and placed under H2 (1 atm) and stirred for 1 h. The mixture, filtered through a 0.45 μm syringe filter and concentrated under reduced pressure provided 4 (98.1 mg, 96%) as a solid: LRESIMS m/z 289.4 [M+H]+, calcd. for C12H9Cl1F3N2O1 289.0.

1. customThe mixture was degassed
2. filtrationThe mixture, filtered through a 0.45 μm syringe
3. filtrationfilter
4. concentrationconcentrated under reduced pressure