2-Fluorobenzoyl chloride → HCID 58487063, compound

HRID 874660Notes

Reaction equation

HRID 874660 reaction equation
[CH3:1][C:2]1[C:10]([C:11]2[N:12]=[CH:13][C:14]([NH2:17])=[N:15][CH:16]=2)=[CH:9][C:8]2[CH2:7][CH2:6][O:5][C:4]=2[CH:3]=1.[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21](Cl)=[O:22]>>[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([NH:17][C:14]1[CH:13]=[N:12][C:11]([C:10]2[C:2]([CH3:1])=[CH:3][C:4]3[O:5][CH2:6][CH2:7][C:8]=3[CH:9]=2)=[CH:16][N:15]=1)=[O:22]

Participants

3

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 58486837HCID 58486837, compound

Product 1

HCID 58487063HCID 58487063, compoundYield 64.9%

Procedure

Similarly, (2-fluorophenyl)-N-[5-(6-methyl(2,3-dihydrobenzo[b]furan-5-yl))-pyrazin-2-yl]carboxamide (167) (6.8 mg, yield: 64.9%, purity>95%) was prepared from 5-(6-methyl-2,3-dihydrobenzo[3,4-b]furan-5-yl)pyrazine-2-ylamine (165) (7.5 mg, 0.03 mmol) and 2-fluorobenzoyl chloride (11 μl).

Sources & evidence

ORD record
ord-6902aa5a0a06439c9d5376beb4bb99d0
Source dataset
uspto-grants-2015_03
Patent number
US08980629B2

Reaction notes

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