Triethylamine → HCID 131732576, compound

Participants

Reaction Conditions

Reaction Steps

1-5 (150 mg, 0.480 mmol) was suspended in CH2Cl2 (10 mL) and cooled to 0° C. To the mixture were added triphosgene (87.0 mg, 0.290 mmol) followed by Et3N (0.140 mL, 0.980 mmol). The mixture was stirred at room temperature for 2 h. The mixture was diluted with CH2Cl2, washed with saturated aqueous NaHCO3, brine and dried over Na2SO4. The residue was triturated with hexane to give 115 mg (82%) of 1-6 as a pale yellow solid: 1H NMR (400 MHz, DMSO-d6) δ 8.34 (1H, br s), 8.09 (2H, m), 8.04 (1H, dd, J=8.4, 0.8 Hz), 8.00 (2H, m), 7.68 (1H, dd, J=8.4, 1.6 Hz); ESI-MS m/z 290 [C16H7N3O3]+.

Provenance & Evidence