tert-Butoxy bis(dimethylamino)methane → (E)-6-(bis(4-methoxybenzyl)amino)-4-(2-(dimethylamino)vinyl)nicotinonitrile

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-3 (7.20 g, 19.3 mmol), tert-butoxy bis(dimethylamino)methane (16.0 mL, 77.5 mmol), and N,N-dimethylformamide (5.40 mL) was stirred at 70° C. for 16 hours under an atmosphere of nitrogen gas. The reaction mixture was concentrated under reduced pressure to give 9.40 g of 4-4 as a brown oil. The crude product was used for next step without further purification.

Provenance & Evidence