Trifluoroacetic acid → HCID 86706878, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 6-(4-iodophenyl)-2,6-diazaspiro[3.3]heptane-2-carboxylate (2.14 g, 5.35 mmol) was dissolved in DCM (10 mL) and cooled to 0° C. TFA (5 mL) was added and then reaction was stirred at 0° C. for 30 min, warmed up to rt and stirred for 1 h. The mixture was concentrated under reduced pressure and purified using a Waters PoraPak Rxn CX 20 cc 2 g cartridge to give the title compound as a white solid (1.51 g, 94%). 1H NMR (400 MHz, CDCl3) 8 ppm 7.45 (d, J=8.5 Hz, 2H), 6.22 (d, J=8.5 Hz, 2H), 3.94 (s, 4H), 3.80 (s, 4H), 1.66 (br. s., 1H); MS ESI 301.0 [M+H]+, calcd for [C11H13IN2+H]+ 301.0.

Provenance & Evidence