HCID 57912188, compound → 2-Methyl-2-[(1-phenethyloxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-propionic acid
Reaction equation
C[O:2][C:3](=[O:21])[C:4]([NH:7][C:8]([C:10]1[CH:19]=[CH:18][C:17]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=2[C:11]=1[OH:20])=[O:9])([CH3:6])[CH3:5].COC(=O)C(NC([C:31]1[CH:32]=[CH:33][C:34]2[CH:38]=[CH:37]S[C:35]=2[C:39]=1O)=O)(C)C>>[CH3:6][C:4]([NH:7][C:8]([C:10]1[CH:19]=[CH:18][C:17]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=2[C:11]=1[O:20][CH2:37][CH2:38][C:34]1[CH:35]=[CH:39][CH:31]=[CH:32][CH:33]=1)=[O:9])([CH3:5])[C:3]([OH:2])=[O:21]Participants
3
Procedure
The following examples were prepared in analogy to example 1 via a sequence of an alkylation reaction to attach a suitably substituted alkylating agent to the aromatic hydroxy group of 2-[(1-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-2-methyl-propionic acid methyl ester or 2-[(7-Hydroxy-benzo[b]thiophene-6-carbonyl)-amino]-2-methyl-propionic acid methyl ester and a basic hydrolysis of the amino acid ester to the free amino acid:
Sources & evidence
- ORD record
- ord-7afe3cf984b94e13a43d9fc265b82ddf
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08980938B2
Reaction notes
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