4-(1,3-Dioxolan-2-ylmethyl)benzoic acid → (R)-Quinuclidin-3-yl((S)-(3-((1-(4-((1,3-dioxolan-2-yl)methyl)benzoyl)piperidin-4-yl)methoxy)phenyl)(phenyl)methyl)carbamate

Participants

Role	Name	HCID	Charge
Reactant	4-(1,3-Dioxolan-2-ylmethyl)benzoic acid	HCID 24726991	—
Reactant	4-((3-((S)-Phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)-phenoxy)methyl)benzoic acid	HCID 86720815	—
Reactant	(R)-quinuclidin-3-yl((S)-phenyl(3-(piperidin-4-ylmethoxy)phenyl)methyl)carbamate	HCID 90210005	—
Product	(R)-Quinuclidin-3-yl((S)-(3-((1-(4-((1,3-dioxolan-2-yl)methyl)benzoyl)piperidin-4-yl)methoxy)phenyl)(phenyl)methyl)carbamate	HCID 90212336	—

Reaction Steps

The title compound was prepared as described in Example 1 Step 11 with (R)-quinuclidin-3-yl((S)-phenyl(3-(piperidin-4-ylmethoxy)phenyl)methyl)carbamate and 4-(1,3-dioxolan-2-ylmethyl)benzoic acid replacing 3-(1,3-dioxolan-2-yl)propyl piperidine-4-carboxylate hydrochloride and 4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid respectively.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08980913B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-3a0677c639fa456d957962ba13a3878b
Source note	uspto-grants-2015_03