3-(5-Methyl-4-oxo-2-(1-[9-(2-trimethylsilylethoxymethyl)-9H-purin-6-ylamino]ethyl)-4H-quinazolin-3-yl)benzamide → 3-{5-Methyl-4-oxo-2-{l-[9H-purin-6-ylamino)-ethyl]-4H-quinazolin-3-yl}-benzamide

HRID 874894Notes

Reaction equation

HRID 874894 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:41])[N:5]([C:32]1[CH:33]=[C:34]([CH:38]=[CH:39][CH:40]=1)[C:35]([NH2:37])=[O:36])[C:6]([CH:12]([NH:14][C:15]1[N:23]=[CH:22][N:21]=[C:20]3[C:16]=1[N:17]=[CH:18][N:19]3COCC[Si](C)(C)C)[CH3:13])=[N:7]2.OC1C=C(N2C(=O)C3C(=CC=CC=3C)N=C2C(NC2N=CN=C3C=2N=CN3)C)C=CC=1>CO>[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:41])[N:5]([C:32]1[CH:33]=[C:34]([CH:38]=[CH:39][CH:40]=1)[C:35]([NH2:37])=[O:36])[C:6]([CH:12]([NH:14][C:15]1[N:23]=[CH:22][N:21]=[C:20]3[C:16]=1[N:17]=[CH:18][NH:19]3)[CH3:13])=[N:7]2

Participants

4

Reactant 2

HCID 666639493-(5-Methyl-4-oxo-2-(1-[9-(2-trimethylsilylethoxymethyl)-9H-purin-6-ylamino]ethyl)-4H-quinazolin-3-yl)benzamideHCID 1784239553-(3-hydroxy-phenyl)-5-methyl-2-[1-(9H-purin-6-ylamino)-ethyl]-3H-quinazolin-4-one

Product 1

HCID 1784239543-{5-Methyl-4-oxo-2-{l-[9H-purin-6-ylamino)-ethyl]-4H-quinazolin-3-yl}-benzamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 143 was treated with 4N HCL in MeOH for 1.5 hours using the procedure described for compound 121 (step D) to provide compound 142. m/z=441 (M+H). The structure of compound 142 is shown below.

Sources & evidence

ORD record
ord-93aaa40174ec4236b58243a04077b9fb
Source dataset
uspto-grants-2015_03
Patent number
US08980901B2

Reaction notes

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