Purine, 6-bromo- → HCID 178448888, compound

HRID 874900Notes

Reaction equation

HRID 874900 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:32])[N:5]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:6]([CH:12]([NH:16][C:17]1[N:25]=[CH:24][N:23]=[C:22]3[C:18]=1[N:19]=[CH:20][NH:21]3)[CH2:13][C:14]#[CH:15])=[N:7]2.[NH2:33]C1N=C2C(NC=N2)=C(Br)N=1.BrC1N=CN=C2C=1NC=N2>>[NH2:33][C:24]1[N:23]=[C:22]2[C:18]([N:19]=[CH:20][NH:21]2)=[C:17]([NH:16][CH:12]([C:6]2[N:5]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:4](=[O:32])[C:3]3[C:8](=[CH:9][CH:10]=[CH:11][C:2]=3[CH3:1])[N:7]=2)[CH2:13][C:14]#[CH:15])[N:25]=1

Participants

4

Reactant 3

HCID 5287830Purine, 6-bromo-HCID 61011392-Amino-6-bromopurineHCID 178448883HCID 178448883, compound

Product 1

HCID 178448888HCID 178448888, compound

Procedure

Compound 165 was prepared following the general procedure described above for the preparation of compound 161, but 2-amino-6-bromopurine was substituted for 6-bromopurine in step D. ESI-MS m/z=437 (MH+).

Sources & evidence

ORD record
ord-08afbc08462b4e9a8394ded794e73568
Source dataset
uspto-grants-2015_03
Patent number
US08980901B2

Reaction notes

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