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HRID874910

反应详情

EQUATION

反应方程式

HRID 874910 的结构方程式

REACTANTS

反应物

4
结构：NCCN
HCID3301

Ethylenediamine

C2H8N2

结构：COc1ccc(S)cc1
HCID12765

Benzenethiol, p-methoxy-

C7H8OS

结构：CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CC(N)=O)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O
HCID5742645

未命名化合物

2 次

结构：[O-]B([O-])Oc1ccccc1
HCID19793864

未命名化合物

PRODUCTS

生成物

1
结构：CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O
HCID2826718

Caspofungin

C52H88N10O15

PROCEDURE

实验过程

According to WO2010008493A2, Pneumocandin B0 as the starting material reacts with 4-methoxy thiophenol, the resulting product is protected by phenyl borate, the amide group in Pneumocandin B0 is reduced to amine group under the condition of dehydration by 3A molecular sieve, and then the resulting product reacts with ethylenediamine to obtain caspofungin.