3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → 6-(2-Methyl-4-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoyl)piperazin-1-yl)nicotinonitrile

Participants

Reaction Steps

This compound was synthesized from 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid and 6-(2-methylpiperazin-1-yl)nicotinonitrile hydrochloride as described for example 37 step 3 (70 mg, yield 43%). 1H NMR (400 MHz, MeOD) δ 8.43 (d, J=2.0 Hz, 1H), 8.27 (m, 1H), 8.22 (s, 1H), 7.78-7.73 (m, 3H), 6.86 (d, J=9.0 Hz, 1H), 4.66-4.56 (m, 2H), 4.34-4.29 (m, 1H), 3.85-3.83 (m, 1H), 3.65 (m, 1H), 3.49-3.40 (m, 1H), 3.26 (m, 1H), 1.29 (m, 3H). MS (ESI) m/z: Calculated for C21H17F3N6O2: 442.14. found: 443.2 (M+H)+.

Provenance & Evidence