Hydrochloric Acid → HCID 67323555, compound

Participants

Reaction Conditions

Reaction Steps

6N HCl (0.5 mL) was added to tert-butyl 4-(5-cyanopyridin-2-yl)-3,5-dimethylpiperazine-1-carboxylate (120 mg, 0.37 mmol) and the reaction mixture was stirred at 90° C. for 30 min. the reaction mixture was cooled to room temperature. The reaction mixture was concentrated under reduced pressure and triturated with ether to afford 6-(2,6-dimethylpiperazin-1-yl)nicotinonitrile (90 mg, crude), which was carried through without further purification. 1H NMR (300 MHz, D2O) δ 8.51 (d, J=2.2 Hz, 1H), 7.93 (dd, J=9.1 Hz, J=2.3 Hz, 1H), 6.97 (d, J=9.2 Hz, 1H), 4.75 (m, 2H), 3.53-3.49 (m, 2H), 3.41-3.34 (m, 2H), 1.42 (s, 3H), 1.39 (s, 3H).

Provenance & Evidence