3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → 6-(1-(3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoyl)piperidin-4-yl)nicotinonitrile

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Reaction Steps

This compound was synthesized from 6-(piperidin-4-yl)nicotinonitrile hydrochloride and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (50 mg, yield 30%). 1H NMR (400 MHz, CDCl3) δ 8.84 (d, J=2.0 Hz, 1H), 8.20-8.19 (m, 2H), 7.95-7.92 (dd, J=8.2 Hz, 2.1 Hz, 1H), 7.67-7.59 (m, 2H), 7.33 (d, J=8.3 Hz, 1H), 4.92 (m, 1H), 3.91 (m, 1H), 3.24 (m, 1H), 3.09 (m, 1H), 2.97 (m, 1H), 2.09 (m, 1H), 1.94-1.83 (m, 3H). MS (ESI) m/z: Calculated for C21H16F3N6O2: 427.13. found: 428.2 (M+H)+

Provenance & Evidence