4-Acetamidopiperidine → HCID 49431041, compound

Participants

Reaction Conditions

Reaction Steps

6-Chloronicotinonitrile (300 mg, 2.1 mmol) and 4-acetylaminopiperidine (610 mg, 4.33 mmol) were taken in isoamyl alcohol (15 mL) and the mixture was heated to 140° C. for 2 h. Reaction mixture was cooled to room temperature and the solvent was evaporated under reduced pressure. The crude product was purified by column chromatography (silica gel 60-120 mesh, eluent 5% MeOH in CHCl3) to afford N-(1-(5-cyanopyridin-2-yl)piperidin-4-yl)acetamide (300 mg, yield 57%) as white solid. 1H NMR (400 MHz, DMSO-d6) δ 8.47 (d, J=2.4 Hz, 1H), 7.83-7.80 (m, 2H), 6.95 (d, J=9.3 Hz, 1H), 4.32-4.28 (m, 2H), 3.89-3.80 (m, 1H), 3.14-3.07 (m, 2H), 1.80 (m, 2H), 1.78 (s, 3H), 1.33-1.24 (m, 2H). MS (ESI) m/z: Calculated for C13H16N4O: 244.13. found: 245.2 (M+H)+

Provenance & Evidence