6-(4-Aminopiperidin-1-yl)pyridine-3-carbonitrile → HCID 53327813, compound

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Reaction Steps

This compound was synthesized from 6-(4-aminopiperidin-1-yl)nicotinonitrile and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (70 mg, yield 41%). 1H NMR (400 MHz, CDCl3) δ 8.42 (m, 2H), 8.27 (d, J=7.8 Hz, 1H), 8.04 (d, J=7.8 Hz, 1H), 7.66-7.61 (m, 2H), 6.67 (d, J=9.0 Hz, 1H), 6.14 (d, J=7.8 Hz, 1H), 4.51-4.48 (m, 2H), 4.39-4.29 (m, 1H), 3.20-3.13 (m, 2H), 2.24-2.20 (dd, J=12.3 Hz, 2.3 Hz, 2H), 1.62-1.52 (m, 2H). MS (ESI) m/z: Calculated for C21H17F3N6O2: 442.14. found: 443.2 (M+H)+

Provenance & Evidence