3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → HCID 67324627, compound

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Reaction Steps

This compound was synthesized from methyl 1-(5-cyanopyridin-2-yl)piperazine-2-carboxylate TFA salt and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (80 mg, yield 82%). 1H NMR (400 MHz, CDCl3) δ 8.43 (d, J=1.0 Hz, 1H), 8.26-8.23 (m, 1H), 8.18 (s, 1H), 7.76-7.73 (dd, J=8.9 Hz, 2.1 Hz, 1H), 7.65-7.64 (m, 2H), 6.73-6.71 (m, 1H), 5.43 (m, 1H), 4.68 (m, 1H), 3.94-3.90 (m, 2H), 3.73-3.68 (m, 3H), 3.59 (m, 2H), 3.28 (m, 1H). MS (ESI) m/z: Calculated for C22H17F3N6O4: 486.13. found: 487.2 (M+H)+

Provenance & Evidence