Trifluoroacetate → 2-(1-Methylpiperazin-2-yl)-4-phenylthiazole

HRID 874970Notes

Reaction equation

HRID 874970 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH:3]1[C:15]1[S:16][CH:17]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:19]=1.FC(F)(F)C([O-])=O>>[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH:3]1[C:15]1[S:16][CH:17]=[C:18]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[N:19]=1

Participants

3

Reactant 2

HCID 84468TrifluoroacetateHCID 70975633Tert-butyl 4-methyl-3-(4-phenylthiazol-2-yl)piperazine-1-carboxylate

Product 1

HCID 673249512-(1-Methylpiperazin-2-yl)-4-phenylthiazole

Procedure

This compound was synthesized from tert-butyl 4-methyl-3-(4-phenylthiazol-2-yl)piperazine-1-carboxylate as described for example 46 step 4 (50 mg, crude) as a trifluoroacetate salt and it was taken as such for the next step. MS (ESI) m/z: Calculated for C14H17N3S: 259.11. found: 260.2 (M+H)+

Sources & evidence

ORD record
ord-34ced8fc2dff4268bc843980e44b69d7
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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