3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → (4-Methyl-3-(4-phenylthiazol-2-yl)piperazin-1-yl)(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)methanone

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Reaction Steps

This compound was synthesized from 2-(1-methylpiperazin-2-yl)-4-phenylthiazole and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (30 mg, yield 32%) as colorless viscous liquid. 1H NMR (400 MHz, CDCl3) δ 8.17-8.16 (m, 2H), 7.93-7.79 (m, 2H), 7.64-7.62 (m, 2H), 7.48-7.32 (m, 4H), 4.78-4.53 (m, 1H), 3.85-3.69 (m, 2H), 3.49-3.30 (m, 2H), 3.17-2.98 (m, 1H), 2.53-2.40 (m, 1H), 2.32 (s, 3H). MS (ESI) m/z: Calculated for C24H20F3N5O2S: 499.12. found: 500.2 (M+H)+

Provenance & Evidence